It's estimated that of the five billion species of organisms that have ever existed on Earth, something like 99.99% of them are extinct. This is with allowances for the fact that -- as I pointed out in a post a couple of years ago -- the word species is one of the mushiest terms in all of science, one of those words that you think you can define rigorously until you realize that every definition you come up with has dozens of exceptions or qualifications.
Be that as it may, there's no doubt that extinction has been the fate of virtually all of the twigs on the Great Tree of Life, from charismatic megafauna like Apatosaurus and the saber-toothed cat all the way down to single-celled organisms that lived and died hundreds of millions of years ago and left no fossil record whatsoever.
Some of the more recent extinctions, though, always strike nature-loving types like myself as a tragedy. The Dodo usually comes up, and the Thylacine (or "Tasmanian wolf," although it wasn't a wolf and wasn't limited to Tasmania), and the maybe-it-still-exists, maybe-it-doesn't Ivory-billed Woodpecker. The Passenger Pigeon, which before 1850 was the most abundant bird in eastern North America, comprising flocks of tens of thousands of individuals, was hunted to extinction in only fifty years -- the last wild Passenger Pigeon was shot in Ohio in 1900.
Wouldn't it be cool, many of us have thought, to bring back some of these lost organisms? The Jurassic Park scenario is a pipe dream; amber notwithstanding, no intact DNA has ever been found from that long ago. But what about more recently-extinct species?
Well, no need to wonder any more. It's been done.
A company called Colossal Biosciences, run by Ben Lamm and George Church, claim to have produced three Dire Wolf pups (Aenocyon dirus) using DNA extracted from a tooth and a skull from Idaho and Ohio, respectively -- genetically altering the fertilized eggs of a gray wolf, and gestating the embryos in ordinary female dogs. Here's one of the results:
You're looking at a photograph of an animal that hasn't lived for ten thousand years.
My initial "good lord this is cool" reaction very quickly faded, though, but not because of some sort of "We're playing God!" pearl-clutching. Lamm, who apparently has huge ambitions and an ego to match, sees no problem with any of it, and has plans to bring back the Dodo and the Woolly Mammoth, and others as well. All, of course, big flashy animals, because that's what attracts investors; no one is going to put millions of dollars into bringing back the Ouachita pebblesnail.
But even that isn't the actual problem, here. Lamm himself gave a glancing touch on the real issue in his interview with The New Yorker (linked above), when someone inevitably brought up Jurassic Park. "That was an exaggerated zoo," Lamm said. "This is letting the animals live in their natural habitats."
No. No, it's not.
Because these species' natural habitats don't exist anymore.
Even the Dodo, which went extinct in 1662, couldn't be reintroduced to Mauritius Island today; the feral cats, rats, dogs, and pigs that helped drive it to extinction in the first place still live in abundance on the island. What would the de-extinction team do? Create a fenced, guarded reserve for it?
How is that not an "exaggerated zoo?"
And the Dire Wolf is an even more extreme example. It originally lived throughout much of the continental United States and down into mountainous regions of Central America. Adults could weigh up to seventy kilograms, so they could take down good-sized prey. If you could create a breeding population of Dire Wolves, where would you put them that they wouldn't come into contact with livestock, pets... and humans?
The truth is sad but inevitable; the world the Dire Wolf lived in is gone forever. Whether what we have now is better or worse is a value judgment I'm not equipped to make. What I do know is that recreating these animals only to have them lead restricted lives in reserves for rich people to come gawk at is morally indefensible. Ultimately, they can never live in the wild again; so a fenced-in reserve -- or the only other option, to let them go extinct a second time.
As huge as the coolness factor is, we shouldn't be doing this. How about putting our time, money, and effort into not further fucking up what we still have? There are plenty of wildlife refuges worldwide that could benefit enormously from the money being sunk into this project. Or, maybe, working toward fighting Donald Trump's "cut down all the trees and strip mine the world" approach to the environment.
So after the first flush of "Wow," all Lamm and Church's accomplishment did was leave me feeling a little sick. There seems to be no end to human hubris, and it's sad that these beautiful animals have to be its showpiece.
It should also be noted that the claim is a Trump-level exaggeration. Inserting several genes that promote some dire wolf characteristics does not even approach creation of the full genomic distinction between dire wolves and grey wolves. Don't forget that gene expression is constrained by the complete genomic environment of the gene (including non-coding "junk" DNA), during every stage of development
ReplyDeleteSo sad that they invested so much in recreating this poor dire wolf when so many species around us are dangerously close to extinction. Save them, not the ones who are already gone!
ReplyDeleteModern gray wolves are not descended from dire wolves, but that’s the stock [Colossal Biosciences] started from.
ReplyDeleteThey made a piddling 20 gene edits to a mere 14 genes , which is not sufficient to turn a wolf into a completely different species.
What they’ve really done is made a mutant wolf and claimed it is a dire wolf.
[quote taken from https://freethoughtblogs.com/pharyngula/2025/04/08/dire-puppies/ ]