Curse to cure

The always-hilarious Gary Larson, whose ability to create absurd combinations of cultural references is unparalleled, had a Far Side comic strip showing a typical office waiting room.  Sitting in one of the chairs, cross-legged and reading a magazine, is a mummy.  The secretary -- with the trademark Larson bouffant hairdo and cat's-eye glasses -- is on the phone to her boss, saying, "Mr. Bailey?  There's a gentleman here who claims an ancestor of yours once defiled his crypt, and now you're the last remaining Bailey, and... oh, something about a curse.  Shall I send him in?"

The whole "Mummy's Curse" thing usually brings to mind the "Boy King" Tutankhamen, and the claim that twenty members of the expedition that opened the tomb died not long afterward.  There are three caveats to this, however: the deaths happened over a decade, suggesting that Tut wasn't in a great hurry to get his vengeance; a statistical study showed that the average age at death of the people who did succumb to "King Tut's Revenge" was no lower than that of the background population; and there is a plausible case to be made that at least two of the deaths (Howard Carter's personal secretary, Richard Bethell, and Bethell's father Lord Westbury, both of whom were murdered) were killed by, or on the orders of, none other than Aleister Crowley.

Whether this last bit is true or not remains very much to be seen; in my opinion, the case relies on highly circumstantial evidence, and after a hundred years it's doubtful we'll ever know for certain.  What I'm pretty sure of is that a scattered bunch of deaths, over ten years or so, of men who were mostly upper middle-aged is not really that much of a mystery, and the curse is nothing more than an attempt to give an added frisson to an archaeological find that honestly is interesting enough without all the supernatural trappings.

On the other hand, consider the opening of the tomb of Casimir IV Jagiellon, King of Poland and Grand Duke of Lithuania.  Casimir is considered one of the most able Polish kings, and consolidated his territory, won many military victories, and generally was a force to be reckoned with.  He died in 1492, and was interred with much pomp and circumstance in Wawel Cathedral in Kraków.

Casimir IV Jagiellon of Poland [Image is in the Public Domain]

In 1973, a team of twelve historians and archaeologists opened his tomb.

Within weeks, ten of the twelve were dead.

So do we have a real-life example of tomb desecration?  Oh, and something about a curse?

It turns out that (unsurprisingly) there's nothing supernatural involved here, either.  No need to invoke ancient Polish witchcraft.  The unfortunate researchers succumbed to infections of Aspergillus flavus, a pathogenic fungus that secretes an especially nasty group of organic compounds called aflatoxins.  Fungal infections are notoriously hard to treat -- fungal cells are similar enough to animal cells that chemicals which will kill a fungus often don't do our own tissues any good at all.  Fungal spores are also incredibly tough and long-lived; the Aspergillus spores that killed the research team members had likely been there since the tomb was sealed, over 530 years ago.

But Aspergillus isn't all bad.  A team at the University of Pennsylvania just published a paper in Nature Chemical Biology looking at a different set of compounds the fungus produces -- and found they target and disrupt cancer cells, especially those in leukemia.

The chemicals are called ribosomally synthesized and post-translationally modified peptides.  The biochemists call them RiPPs, even though the actual acronym would be RSaPTMPs, which I have to admit would be a little hard to pronounce, so RiPPs it is.  And the scientists found that the RiPPs produced by Aspergillus flavus had as much potency against leukemia cells as cytarabine and daunorubicin, two of the go-to drugs used to treat the disease for decades.

"Nature has given us this incredible pharmacy," said Sherry Gao, senior author of the study.  "It's up to us to uncover its secrets.  As engineers, we're excited to keep exploring, learning from nature and using that knowledge to design better solutions."

Which I think you will all agree is a better approach than superstition about opening graves.

Still, it's probably best to be cautious in any tomb-raiding you're planning on doing.  Curses not withstanding, aspergillosis is nothing to mess around with.  Even if the fungus turns out to have some beneficial features, remember to wear your respirators the next time you investigate the burial sites of fifteenth-century Polish kings.

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