Skeptophilia (skep-to-fil-i-a) (n.) - the love of logical thought, skepticism, and thinking critically. Being an exploration of the applications of skeptical thinking to the world at large, with periodic excursions into linguistics, music, politics, cryptozoology, and why people keep seeing the face of Jesus on grilled cheese sandwiches.
Showing posts with label bacteriophages. Show all posts
Showing posts with label bacteriophages. Show all posts

Thursday, September 15, 2022

Viral reality

If you are of the opinion that more evidence is necessary for demonstrating the correctness of the evolutionary model, I give you: a paper by biologist Justin R. Meyer of the University of California-San Diego et al. that has conclusively demonstrated speciation occurring in the laboratory.

The gist of what the team did is to grow populations of bacteriophage Lambda (a virus that attacks and kills bacteria) in the presence of populations of two different potential food sources, more specifically E. coli that had one of two different receptors where the virus could attach.  What happened was that the original bacteriophages were non-specialists -- they could attach to either receptor, but not very efficiently -- but over time, more of them accrued mutations that allowed them to specialize in attacking one receptor over the other.  Ultimately, the non-specialists became extinct, leaving a split population where each new species could not survive on the other's food source.


Diagram of a bacteriophage [Image is in the Public Domain]

Pretty amazing stuff.  My response was, "If that isn't evolution, what the hell is it?"  Of course, I'm expecting the litany of goofy rejoinders to start any time now.  "It's only microevolution."  "There was no novel gene produced."  "But both of them are still viruses.  If you showed me a virus evolving into a wombat, then I'd believe you."

Nevertheless, this sticks another nail in the coffin of the anti-evolutionists -- both Intelligent Design proponents and the young-Earth creationists, the latter of whom believe that all of the Earth's species were created as-is six thousand or so years ago along with the Earth itself, and that the two hundred million year old trilobite fossils one sometimes finds simply dropped out of God's pocket while he was walking through the Garden of Eden or something.

So as usual, you can't logic your way out of a stance you didn't logic your way into.  Still, I have hope that the tide is gradually turning.  Certainly one cheering incident comes our way from Richard Lenski, who is justly famous for his groundbreaking study of evolution in bacteria and who co-authored the Meyer paper I began with.  But Lenski will forever be one of my heroes for the way he handled Andrew Schlafly, who runs Conservapedia, a Wikipedia knockoff that attempts to remodel the world so that all of the ultra-conservative talking points are true.  Schlafly had written a dismissive piece about Lenski's work on Conservapedia, to which Lenski responded.  The ensuing exchange resulted in one of the most epic smackdowns by a scientist I've ever seen.  Lenski takes apart Schlafly's objections piece by piece, citing data, kicking ass, and taking names.  I excerpt the end of it below, but you can (and should) read the whole thing at the article on the "Lenski Affair" over at RationalWiki:
I know that I’ve been a bit less polite in this response than in my previous one, but I’m still behaving far more politely than you deserve given your rude, willfully ignorant, and slanderous behavior.  And I’ve spent far more time responding than you deserve.  However, as I said at the outset, I take education seriously, and I know some of your acolytes still have the ability and desire to think, as do many others who will read this exchange.

Sincerely, Richard Lenski
And if that's not spectacular enough, check out one of the four P.S.s:
I noticed that you say that one of your favorite articles on your website is the one on “Deceit.”  That article begins as follows: “Deceit is the deliberate distortion or denial of the truth with an intent to trick or fool another.  Christianity and Judaism teach that deceit is wrong.  For example, the Old Testament says, ‘Thou shalt not bear false witness against thy neighbor.’”  You really should think more carefully about what that commandment means before you go around bearing false witness against others.
I can only hope that there was a mic around after that so that Lenski could drop it.

So there you have it.  Science finding out cool stuff once again, because after all, that's what science does.  The creationists, it is to be hoped, retreating further and further into the corner into which they've painted themselves.  It's probably a forlorn wish that this'll make Ken Ham et al. shut up, but maybe they'll eventually have to adapt their strategy to address reality instead of avoiding it.

You might even say... they'll need to evolve.

****************************************


Monday, March 29, 2021

Viral reality

If you are of the opinion that more evidence is necessary for demonstrating the correctness of the evolutionary model, I give you: a paper by biologist Justin R. Meyer of the University of California-San Diego et al. that has conclusively demonstrated speciation occurring in the laboratory.

The gist of what the team did is to grow populations of bacteriophage Lambda (a virus that attacks and kills bacteria) in the presence of populations of two different potential food sources, more specifically E. coli that had one of two different receptors where the virus could attach.  What happened was that the original bacteriophages were non-specialists -- they could attach to either receptor, but not very efficiently -- but over time, more of them accrued mutations that allowed them to specialize in attacking one receptor over the other.  Ultimately, the non-specialists became extinct, leaving a split population where each new species could not survive on the other's food source.

Diagram of a bacteriophage [Image licensed under the Creative Commons GrahamColm at English Wikipedia, Phage, CC BY-SA 3.0]

Pretty amazing stuff.  My response was, "If that isn't evolution, what the hell is it?"  Of course, I'm expecting the litany of goofy rejoinders to start any time now.  "It's only microevolution."  "There was no novel gene produced."  "But both of them are still viruses.  If you showed me a virus evolving into a wombat, then I'd believe you."

"Anti-evolutionists," see "Goalposts, Moving the."

Nevertheless, this sticks another nail in the coffin of both Intelligent Design proponents and the young-Earth creationists, the latter of whom believe that all of the Earth's species were created as-is six thousand or so years ago along with the Earth itself, and that the two hundred million year old trilobite fossils one sometimes finds simply dropped out of God's pocket while he was walking through the Garden of Eden or something.

So as usual, you can't logic your way out of a stance you didn't logic your way into.  Still, I have hope that the tide is gradually turning.  Certainly one cheering incident comes our way from Richard Lenski, who is justly famous for his groundbreaking study of evolution in bacteria and who co-authored the Meyer paper I began with.  But Lenski will forever be one of my heroes for the way he handled Andrew Schlafly, who runs Conservapedia, a Wikipedia clone that attempts to remodel reality so that all of the ultra-conservative talking points are true.  Schlafly had written a dismissive piece about Lenski's work on Conservapedia, to which Lenski responded.  The ensuing exchange resulted in one of the most epic smackdowns by a scientist I've ever seen.  Lenski takes apart Schlafly's objections piece by piece, citing data, kicking ass, and taking names.  I excerpt the end of it below, but you can (and should) read the whole thing at the article on the "Lenski Affair" over at RationalWiki:
I know that I’ve been a bit less polite in this response than in my previous one, but I’m still behaving far more politely than you deserve given your rude, willfully ignorant, and slanderous behavior.  And I’ve spent far more time responding than you deserve.  However, as I said at the outset, I take education seriously, and I know some of your acolytes still have the ability and desire to think, as do many others who will read this exchange.

Sincerely, Richard Lenski
And if that's not spectacular enough, check out one of the four P.S.s:
I noticed that you say that one of your favorite articles on your website is the one on “Deceit.”  That article begins as follows: “Deceit is the deliberate distortion or denial of the truth with an intent to trick or fool another.  Christianity and Judaism teach that deceit is wrong.  For example, the Old Testament says, ‘Thou shalt not bear false witness against thy neighbor.’”  You really should think more carefully about what that commandment means before you go around bearing false witness against others.
I can only hope that there was a mic around after that so that Lenski could drop it.

So there you have it.  Science finding out cool stuff once again, because after all, that's what science does.  The creationists, it is to be hoped, retreating further and further into the corner into which they've painted themselves.  It's probably a forlorn wish that this'll make Ken Ham shut up, but maybe he'll eventually have to adapt his strategy to address reality instead of avoiding it.

You might even say... he'll need to evolve.

*********************************

The sad truth of our history is that science and scientific research has until very recently been considered the exclusive province of men.  The exclusion of women committed the double injury of preventing curious, talented, brilliant women from pursuing their deepest interests, and robbing society of half of the gains of knowledge we might otherwise have seen.

To be sure, a small number of women made it past the obstacles men set in their way, and braved the scorn generated by their infiltration into what was then a masculine world.  A rare few -- Marie Curie, Barbara McClintock, Mary Anning, and Jocelyn Bell Burnell come to mind -- actually succeeded so well that they became widely known even outside of their fields.  But hundreds of others remained in obscurity, or were so discouraged by the difficulties that they gave up entirely.

It's both heartening and profoundly infuriating to read about the women scientists who worked against the bigoted, white-male-only mentality; heartening because it's always cheering to see someone achieve well-deserved success, and infuriating because the reason their accomplishments stand out is because of impediments put in their way by pure chauvinistic bigotry.  So if you want to experience both of these, and read a story of a group of women who in the early twentieth century revolutionized the field of astronomy despite having to fight for every opportunity they got, read Dava Sobel's amazing book The Glass Universe: How the Ladies of the Harvard Observatory Took the Measure of the Stars.

In it, we get to know such brilliant scientists as Willamina Fleming -- a Scottish woman originally hired as a maid, but who after watching the male astronomers at work commented that she could do what they did better and faster, and so... she did.  Cecilia Payne, the first ever female professor of astronomy at Harvard University.  Annie Jump Cannon, who not only had her gender as an unfair obstacle to her dreams, but had to overcome the difficulties of being profoundly deaf.

Their success story is a tribute to their perseverance, brainpower, and -- most importantly -- their loving support of each other in fighting a monolithic male edifice that back then was even more firmly entrenched than it is now.  Their names should be more widely known, as should their stories.  In Sobel's able hands, their characters leap off the page -- and tell you a tale you'll never forget.

[Note: if you purchase this book using the image/link below, part of the proceeds goes to support Skeptophilia!]



Friday, December 9, 2016

Viral reality

If you are of the opinion that more evidence is necessary for demonstrating the correctness of the evolutionary model, I give you: a paper by biologist Justin R. Meyer of the University of California-San Diego et al. that has conclusively demonstrated speciation occurring in the laboratory.

The gist of what the team did is to grow populations of bacteriophage Lambda (a virus that attacks and kills bacteria) in the presence of populations of two different potential food sources, more specifically E. coli that had one of two different receptors where the virus could attach.  What happened was that the original bacteriophages were non-specialists -- they could attach to either receptor, but not very efficiently -- but over time, more of them accrued mutations that allowed them to specialize in attacking one receptor over the other.  Ultimately, the non-specialists became extinct, leaving a split population where each new species could not survive on the other's food source.

Diagram of a bacteriophage [image courtesy of the Wikimedia Commons]

Pretty amazing stuff.  My response was, "If that isn't evolution, what the hell is it?"  Of course, I'm expecting the litany of goofy rejoinders to start any time now.  "It's only microevolution."  "There was no novel gene produced."  "But both of them are still viruses.  If you showed me a virus evolving into a wombat, then I'd believe you."

Nevertheless, this sticks another nail in the coffin of the anti-evolutionists -- both Intelligent Design proponents and the young-Earth creationists, the latter of whom believe that all of the Earth's species were created as-is 6,000 or so years ago along with the Earth itself, and that the 200 million year old trilobite fossils one sometimes finds simply dropped out of god's pocket while he was walking through the Garden of Eden or something.

So as usual, you can't logic your way out of a stance you didn't logic your way into.  Still, I have hope that the tide is gradually turning.  Certainly one cheering incident comes our way from Richard Lenski, who is justly famous for his groundbreaking study of evolution in bacteria and who co-authored the Meyer paper I began with.  But Lenski will forever be one of my heroes for the way he handled Andrew Schlafly, who runs Conservapedia, a Wikipedia clone that attempts to remodel the world so that all of the ultra-conservative talking points are true.  Schlafly had written a dismissive piece about Lenski's work on Conservapedia, to which Lenski responded.  The ensuing exchange resulted in one of the most epic smackdowns by a scientist I've ever seen.  Lenski takes apart Schlafly's objections piece by piece, citing data, kicking ass, and taking names.  I excerpt the end of it below, but you can (and should) read the whole thing at the article on the "Lenski Affair" over at RationalWiki:
I know that I’ve been a bit less polite in this response than in my previous one, but I’m still behaving far more politely than you deserve given your rude, willfully ignorant, and slanderous behavior.  And I’ve spent far more time responding than you deserve.  However, as I said at the outset, I take education seriously, and I know some of your acolytes still have the ability and desire to think, as do many others who will read this exchange. 
Sincerely, Richard Lenski
And if that's not spectacular enough, check out one of the four P.S.s:
I noticed that you say that one of your favorite articles on your website is the one on “Deceit.”  That article begins as follows: “Deceit is the deliberate distortion or denial of the truth with an intent to trick or fool another. Christianity and Judaism teach that deceit is wrong.  For example, the Old Testament says, ‘Thou shalt not bear false witness against thy neighbor.’”  You really should think more carefully about what that commandment means before you go around bearing false witness against others.
I can only hope that there was a mic around after that so that Lenski could drop it.

So there you have it.  Science finding out cool stuff once again, because after all, that's what science does.  The creationists, it is to be hoped, retreating further and further into the corner into which they've painted themselves.  It's probably a forlorn wish that this'll make Ken Ham shut up, but maybe he'll eventually have to adapt his strategy to address reality instead of avoiding it.

You might even say... he'll need to evolve.

Friday, January 9, 2015

Zombie nanobots from hell

For the latest reason that you should avoid being vaccinated, as long as you have zero understanding of science, we have:

The medical establishment puts nanobots into vaccines, which then eat your brain.

This, at least, is the contention of one Jim Stone, who runs a site called Environmental Terrorism.  And it turns out that the nanobot doesn't eat your whole brain, it just destroys the part of it that allows you to go to heaven:
(A) virus they are creating will attack the “God Center” of the brain and destroy it! He tries to sell it by saying that this will stop suicide bombers by people that believe in God but of course this is just the sell job.  He says it will take somebody that believes in God and turn them into a “normal” person!  So if you’re a Christian it will make you no longer believe in God and Jesus Christ which is your key to eternal life!  This is the pure evil that is the new world order government running the US!
Well.  Isn't that special.  But in the parlance of the 1980s infomercial, "Wait!  There's more!"
There have been many reports about nanobots being developed that will destroy people. This report actually identifies that nanobot and what it is based upon. Once this nanobot is received via a tainted vaccine, it inserts DNA into your cells which instructs your own cells to produce more copies of itself and THAT is how it replicates. And it NEVER backs off, it simply orders your own cells to keep producing it until your cells die from being over worked doing exactly that. And it’s completely verified this thing came from a lab in 2007.
You have no idea how relieved I was when I read the last sentence, because I got the majority of my vaccinations before 2007.  Which, presumably, is why I still have a brain.

Who would do this evil stuff, you might ask?  And of course, the answer is:

The Jews.  But you probably already knew that.

I plan on asking my wife, who is Jewish, why she would do such a thing.  I mean, making me eat matzoh balls, which in my opinion taste like chicken-flavored play-doh, is one thing.  Infecting me with a microorganism that eats my brain is quite another.

Then Mr. Stone shows us a picture of the nanobot that does all of this nasty business:


When I saw this, I said to my computer, and I quote:  "What the fuck?  That's a bacteriophage."

But this doesn't stop Mr. Stone.  He claims that this creature didn't exist prior to 2007, which will surprise the hell out of my AP Biology students because I've been teaching them about bacteriophages ("bacteria-eating viruses") since 1994.  It's also quite natural, and completely harmless unless you're an E. coli bacterium.

You'd think that an amount of research that's as microscopic as the virus itself would be sufficient to convince Mr. Stone that his claim is complete and utter horse waste.  Starting with the fact that it's called a "bacteriophage," and not a "brainophage."  But no.  Not only is this thing going to turn you into an irreligious zombie, you can tell it's a Jewish nanobot because of its shape:
(T)heir little hexagonal leg patterns and star of david phage bodies (are wreaking) havoc on the rest of mankind.  And on that note, I may have stated above that the reason for re engineering a phage to do the job rather than a known infectious virus would be to make good and sure it could not spread to other people in the wild, but I can´t help but imagine that such a profoundly Jewish looking micro organism would not be selected simply for its appearances.
A passage which, I suppose, demonstrates why Mr. Stone himself is immune.  If you don't have a functioning brain, that would presumably make the Jewish brain-eating nanobot virus less interested in infecting you.

At the end, we get the coup de grâce:
(E)verybody must make their own decisions about vaccines.  I’m not a doctor and cannot give you medical advice.  All I’m saying is that evil men control the medical system and they already have a virus that can change your brain so you no longer believe in God!
Have a nice day.

So, there you have it.  The least plausible reason yet that the anti-vaxxers are suggesting that you not get vaccinated.  At least it's more fanciful than Jenny McCarthy and her hand-waving "vaccines cause autism" nonsense.  Given a choice between Jenny McCarthy and brain-destroying nanobots, I'll take my chance with the nanobots.