Expertise

The attitude of many laypeople toward medical science can be summed up as "all you have to do is."

Never mind those silly experts, who actually went to medical school and all.  All you have to do is (choose one or more):

• take vitamins (two favorites are C and D)
• spend more time outdoors
• get more exercise
• get more exposure to sunshine
• drink more water
• stop eating meat
• eat more probiotics
• eat more protein
• eat less protein
• eat less processed food
• eat less sugar
• eat less salt
• eat less, period

Now, mind you, I'm not saying these are bad ideas, with the exception of eating both more and less protein, which are hard to do at the same time.  Most of us could use more exercise and eating less sugar and salt, for example.  It's just that the "all you have to do is" attitude tries to boil down all medical conditions to some easily understandable, easily treated set of causes, and avoids the scary truth that human health is complicated.

Sometimes so complicated that even the experts are stumped.

One of the weirdest examples of that latter phenomenon is a ten-year-long epidemic that happened in the early twentieth century, which directly caused at least a half a million deaths worldwide, and that even so most people haven't heard of.  It's called encephalitis lethargica, but that's really only a description of its symptoms; encephalitis means "brain swelling," and lethargica -- well, that one's obvious.  The first cases in the epidemic (although as you'll see, perhaps not the first cases ever) happened in 1915, and just about all of the patients experienced the same, very odd progression of symptoms:

• first, sore throat, headache, and lethargy
• double vision and an uncontrollable upward motion of the eyes ("oculogyric crisis") 
• upper body weakness, spasms, and neck rigidity
• "sleep inversion" -- the drive to sleep during the day and be awake at night
• temper tantrums, psychosis, and hypersexuality
• "klazomania" -- compulsive screaming
• catatonia

The most commonly effected were males between the ages of five and eighteen, but people of all genders and ages could (and did) get the disease.  The mortality rate was high -- about half of the known victims died within a year of onset -- and of the ones who survived, a great many had neurological problems for the rest of their lives, with many of them exhibiting emotional disturbances and/or Parkinsonism.

The disease is sometimes called Economo's disease, after Austrian neurologist Constantin von Economo,  who along with French pathologist Jean-René Cruchet wrote several papers describing the pathology, symptoms, and treatments (the latter, mostly unsuccessful) for it.

Medical journal photographs from 1920, showing Constantin von Economo (upper left) along with four patients suffering from encephalitis lethargica [Image is in the Public Domain]

To cut to the punch line: we still have no idea what caused it.

Initially, it was thought to have something to do with the Spanish flu, which happened around the same time -- possibly an autoimmune reaction triggered by the flu virus -- but that hypothesis was ruled out because there seems to be no correlation between the disease and previous flu exposure.  Also, the Spanish flu pandemic ended in 1919, while the epidemic of encephalitis lethargica went on until 1926.  (This by itself doesn't eliminate a connection; odd immune reactions occurring long after exposure are relatively common, such as shingles turning up years after contracting, and recovering from, chicken pox.)  The brilliant writer Oliver Sacks, in his book Awakenings, stated that the most likely culprit was an enterovirus, a group that contains the causative pathogen of another multi-symptom disease -- polio -- as well as the Coxsackie viruses, thought to play a role in such autoimmune diseases as type 1 diabetes, myalgic encephalomyelitis, and Sjögren's syndrome.  This contention, however, is still considered speculative at best.

While the 1915-1926 outbreak was the most serious, medical historians have identified other epidemics that may be encephalitis lethargica in Europe -- 1580, 1674, 1712, and 1890.  Because there's no certainty of the cause of the 1915 outbreak, it's hard to be sure these are the same disease, but from the symptoms they sound similar.

The reason I bring all this up today is more than just a chance to talk about a biological oddity.  It's to point out that human physiology, and all the things that can go wrong with it, are complex topics.  Emergent diseases like encephalitis lethargica are scary precisely because they strike suddenly and hard, then can vanish before we have much of a chance to study them (and potentially prevent subsequent outbreaks).

And -- the crucial point -- when they do, we need the best-trained minds in medical science to have every tool at their disposal.

Which, in the United States, we don't.  At the moment, the head of the Department of Health and Human Services is a loony anti-vaxxer who is still trying to connect vaccines to autism despite massive study after massive study showing there's no correlation, much less a causation.  His latest salvo was touting putting cane sugar back into Coke as a major victory in "Making America Healthy Again," despite the fact that it's hard for me to see how anything involving drinking Coke would foster better health.  There's a real concern that because of his policies we may have significant shortages of the flu and COVID-19 vaccines this fall, raising the specter of unchecked epidemics.  Research into cancer treatment -- including an mRNA vaccine that shows great promise in treating deadly pancreatic cancer -- have had their funding pulled.

Oh, but according to RFK Jr., that's not a problem.  "All you have to do" to remain healthy is spend more time outdoors and take vitamins.

This is the man in charge of our health policy today.

Look, I know all too well that there were serious problems with the American medical system even before RFK was appointed.  Overpresciption of antibiotics, opioids, antidepressants, and anxiolytics.  Necessary medical procedures being denied by avaricious insurance companies.  Getting the runaround from GP to specialist and back again, with the result that treatment can be delayed weeks to months.  My wife's a registered nurse; don't think I'm unaware of the issues.

But.  If I were to develop a serious medical condition, I'd still want trained experts working on it.  Why on earth would I not?  How does it make sense to doubt medical expertise, when we trust expertise of just about every other sort?  No one gets on an airplane and says, "To hell with training, I'm okay if the plane is piloted by a plumber who has never flown before."  When your house's wiring needs work, you don't say, "I'm fine hiring an accountant to do the job.  He'll do just as well as an actual electrician."  People of all professions work long and hard to acquire their skills and knowledge, and by and large, we trust that they know what they're doing within their given fields.

So why have we been told that medical researchers are somehow the only ones who are lying to us?  And why do so many believe it?

I wish I knew the answer to that.  Maybe it's just because with something as complex and potentially scary as our health, we tend to flail around for something, anything, to make it simpler and more reassuring.  And it's a sad truth of life that sometimes the answers evade even the experts.  The outbreak of encephalitis lethargica is just one of many examples.  But when the next mystery disease strikes -- or even some of the familiar ones -- we want the best shot we have to respond quickly and effectively.

And for that, we need trained doctors and researchers, not anti-science ideologues.

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Trojan horse

Well, I just ran into the single stupidest conspiracy theory in existence.

Don't even try to convince me there's a dumber one, because I don't want to hear it.  HAARP controlling hurricanes and tornadoes to target enemies?  Pshaw.  A global network of Illuminati in league with Reptilian aliens to control major world governments?  Amateur hour.  Big Pharma putting mind-control microchips in our meds to turn us all into soulless automata?  Little League.

Because now we have: the COVID vaccine is "installed with payloads" of the Marburg virus, which will be activated in October by a signal broadcast from 5G networks, triggering the zombie apocalypse and killing billions, starting with all of the people who were foolish enough to get vaccinated.  This will result in the Evil Democrats winning (for that, read stealing) the 2024 election.

*brief pause for you to regain your equilibrium*

Okay, some background first.

Marburg virus [Image licensed under the Creative Commons The University of Texas Medical Branch at Galveston. https://www.utmb.edu/newsroom/article11484.aspx, 137488 web, CC BY-SA 4.0]

Marburg virus causes a deadly hemorrhagic fever similar to the better-known (and related) Ebola virus.  It's a bad one; there's no vaccine yet, and even with treatment the mortality rate is somewhere between sixty and eighty percent.  It's endemic in certain parts of Africa, and seems to be carried by bats and monkeys.  It's considered to be of significant concern with regards to epidemics, given how contagious it is.

However, there is no way to (1) put it into some kind of Trojan horse in a vaccine, and (2) activate it using a 5G signal (or any other kind of signal).  In order to believe this, you have to know essentially nothing about viruses, vaccines, or 5G.

Which is apparently the case with Todd Callender, who seems to have been the origin of this particular lunacy back in 2022.  He appeared in an interview with Jeffrey Prather on his program The Prather Point, and we're assured that Callender isn't "some hare-brained fringe theorist" because Prather vets all of his guests and he says so.

So that's good to know. 

"A broadcast from 5G cell towers at 18 MHz, for a specific duration and sequence, will cause affected cells to rupture," Callender said, "unleashing Marburg payload bioweapons into the blood of those who took the mRNA injections.  This, in turn, would instantly unleash a Marburg pandemic and produce a sudden rush of symptoms including bleeding out (hemorrhagic fever isn't pretty), cardiovascular deaths, seizures and more.  Some of the symptoms that could appear would even resemble classic zombies as depicted in pop culture; biting, loss of cognitive function, aggression, confusion and extreme alterations in the appearance of skin and eyes, among other similarities."

The ultimate outcome is that the Democrats (who, of course, engineered all this) will swipe the 2024 election.  "If this theory pans out, the obvious timeframe for the powers that be to release the binary weapon would be before the [next election]...  With a whole new pandemic hitting the scene -- with far more serious symptoms and a higher death rate compared to COVID -- the elections could either be cancelled or altered into a universal vote-from-home format which would favor the highly organized vote rigging and ballot counterfeiting of the Democrats (who are only in power because they stole the last election, of course)."

For all the doubters in the studio audience, we're told to stop being KoolAid-drinkin' sheeple.  "Critics might say this all smacks of science fiction.  But we are living through a science fiction dystopian scenario right now, with extreme censorship, an Orwellian global cabal trying to exterminate the human race, the rise of the robots and the mass injection of billions of people with exotic nanotechnology that seems to have a rather nefarious purpose, far from merely offering 'immunity.'"

The last bit reminds me of the wonderful quote by Carl Sagan: "The fact that some geniuses were laughed at does not imply that all who are laughed at are geniuses.  They laughed at Columbus, they laughed at Fulton, they laughed at the Wright brothers.  But they also laughed at Bozo the Clown."

In any case, we don't have long to wait, since the latest intel is that this is all going down in October.  Me, I'm kind of bummed by that, because my birthday's in October, and I was rather looking forward to having a nice quiet celebration with my wife, and not having to stumble around the village bleeding from the eye sockets and looking for brains to eat.

But I'll return to my original point, which is that if there is a stupider conspiracy theory out there, I don't want to know about it.  Writing about all this made me long for the good old days when the antivaxxers were content to inject bleach and swallow horse dewormer.

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The mystery plague

Ever heard of cocoliztli?

In one way, it's shocking if you haven't, and in another, hardly surprising at all, because the vast majority of its victims were the indigenous people of Mexico and Central America, and history has a way of ignoring what happened to brown-skinned people.  Cocoliztli is the Nahuatl name for a contagious, usually fatal disease that struck Mesoamerica repeatedly, with the worst recorded outbreaks in the sixteenth century, killing an estimated ten million people.  This puts it in fifth place for the worst pandemics known, after the Black Death (estimated one hundred million casualties), Justinian's plague (fifty million), HIV/AIDS (forty million), and the Spanish flu (thirty million).  [Nota bene: if we're adding up total death toll, one of the worst is smallpox, but as that was endemic and widespread, I'm not counting that as a true pandemic.  In eighteenth-century Europe, for example, it's estimated that four hundred thousand people died of smallpox per year; and its introduction into the Americas decimated Native populations.  It's likely we'll never know for sure how big the death toll was, but it was huge.]

The symptoms of cocoliztli were awful.  Severe headache, high fever, vertigo, jaundice, and abdominal cramps.  The worst was the hemorrhaging -- victims bled from every orifice including the tear ducts.  Most of the victims died, usually between four and seven days after onset.

[Image is in the Public Domain]

There are two curious things about cocoliztli.  The first is that there hasn't been a confirmed case of it since 1813.

So where has it gone?  Ordinarily, infectious diseases occur at low rates until a confluence of events triggers a more widespread outbreak.  Consider, for example, the Black Death.  Bubonic plague (caused by the bacteria Yersinia pestis) has been present in humans for millennia, but a perfect storm occurred in the mid-fourteenth century that caused the most devastating pandemic in history.  First, it was the beginning of the Little Ice Age, and the lower temperatures drove rats (and the fleas they carried) indoors, and into contact with humans.  Second, trade throughout Europe, and with Asia (via the Silk Road), had really just started to gear up, and rats are notorious for stowing away on ships.  And third, the population had risen -- and larger, more crowded cities facilitate disease spread.

Cocoliztli, though, hit Mesoamerica hard, and seemingly out of nowhere.  Repeated outbreaks in 1545, 1576, 1736, and 1813 killed millions, but in between, we don't know where it went -- or why after 1813 it apparently vanished completely.

The second odd thing is that we still don't know what caused it.

The bones of presumed victims have offered up only debatable information.  Back in 2018, Johannes Krause, of the Max Planck Institute for the Science of Human History, found DNA in bones from victims of the 1545 outbreak that seems to come from a Salmonella enterica strain called Paratyphi C, but that doesn't mean that's what killed them -- and one epidemiologist has pointed out that typhoid fever, which is caused by S. enterica, doesn't have the same symptoms as cocoliztli.  Others suggest that its symptoms are more consistent with a viral hemorrhagic fever like Ebola, Lassa, and Marburg, but there are no viruses known that are endemic to the Americas and cause symptoms like that.

A rather sobering possibility is that the pathogen, whatever it is, resides in an animal vector -- that is, it's a zöonotic disease, one that exists in an animal population and is reintroduced to humans periodically upon contact.  If so, it's unknown what that vector might be -- but the jungles of Central America are a big place, and there are lots of animals there in which a pathogen might hide.

Whatever causes it, and wherever it went, it's to be hoped it's gone for good.  This would put it in the same class as the mysterious European sweating sickness, that caused repeated outbreaks in the late fifteenth and early sixteenth centuries, and then vanished, apparently permanently.  It, like cocoliztli, was highly infectious -- but the pathogen remains unidentified.

Cocoliztli left its mark on history.  The population of Mexico collapsed in the sixteenth century, largely due to the outbreaks, dropping from an estimated twenty-two million in 1500 to two million a hundred years later.  This undoubtedly contributed to the Spanish takeover -- something that reverberates to the present day.

It's also an enduring mystery.  How such a virulent disease could strike so hard, decimating an entire region, and then vanish utterly is bizarre.  But it does highlight how important epidemiological research is -- helping us to understand how pathogens cause disease, and how they jump from one host to the other.  Giving us, it is to be hoped, the tools for stopping the next pandemic before it happens.

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A commerce in death

My novella We All Fall Down is set during some of the most awful years humanity has ever lived through -- the middle of the fourteenth century, when by some estimates between a third and half of the people in Eurasia died of the bubonic plague, or as they called it, the "Black Death."

Back then, of course, no one knew what caused it.  Not only that the disease came from a microscopic organism, but that it was carried by fleas and spread by the rats that carried them.  The superstition of the time meant that people became desperate to find out why this catastrophe had occurred, and the blame was placed on everything from God's wrath to evil magic by witches, warlocks, and (unfortunately for them), the Jews.

It's natural enough to try to figure out ultimate causes, I suppose, even though they can be elusive.  I tried to express this in words of the narrator of We All Fall Down, the young, intelligent, inquisitive guardsman Nick Calladine, who has found himself entangled in a situation completely beyond his comprehension:

I asked Meg if she would be all right alone, and she said she would.  There were one or two other villagers who had survived the plague, and they were helping each other, and for now had enough to eat.  I wondered what would happen when winter came, but I suppose that their plight was no different from that of many in England.  Some would make it, some would not, and that was the way of things.  We are not given to understand much, we poor mortals.  The religious say that after we die we will understand everything, and see the reasons that are dark to us now, but I wonder.  From what I have seen, things simply happen because they happen, and there is no more pattern in the world than in the path a fluttering leaf takes on the wind.  To say so would be considered heresy, I suppose, but so it has always seemed to me.

The proximal cause of the Black Death -- rats, fleas, and the bacterium Yersinia pestis -- doesn't explain why the disease suddenly caught hold and exploded its way through the population.  One of the more plausible explanations I've heard is that climatic changes were the root cause; the Northern Hemisphere was at the time in the beginning of the "Little Ice Age," and the colder, harsher weather caused crop failure and a general shortage of food.  This not only weakened the famine-struck humans, but it drove rats indoors -- and into contact with people.

Seventeenth-century "plague panel" from Augsburg, Germany, hung on the doors of houses to act as a talisman to ward off illness [Image is in the Public Domain]

The reason all this dark stuff comes up is that a new study, by a team led by Maria Spyrou of the Eberhard Karls University of Tübingen and the Max Planck Institute, has added another piece to the puzzle.  Using a genetic analysis of bones from a cemetery in Kyrgyzstan, which lay beneath a stone whose inscription indicated they'd died of the plague, Spyrou et al. found that not only did the DNA from remnants of Y. pestis in the bones match those of European plague victims, it matched extant reservoirs of the bacteria in animals from the nearby Tian Shan Mountains.

The authors write:

The onset of the Black Death has been conventionally associated with outbreaks that occurred around the Black Sea region in 1346, eight years after the Kara-Djigach epidemic [that killed the people whose bones were analyzed in the study].  At present, the exact means through which Y. pestis reached western Eurasia are unknown, primarily due to large pre-existing uncertainties around the historical and ecological contexts of this process.  Previous research suggested that both warfare and/or trade networks were some of the main contributors in the spread of Y. pestis.  Yet, related studies have so far either focused on military expeditions that were arguably unrelated to initial outbreaks or others that occurred long before the mid-fourteenth century.  Moreover, even though preliminary analyses exist to support an involvement of Eurasian-wide trade routes in the spread of the disease, their systematic exploration has so far been conducted only for restricted areas of western Eurasia.  The placement of the Kara-Djigach settlement in proximity to trans-Asian networks, as well as the diverse toponymic evidence and artefacts identified at the site, lend support to scenarios implicating trade in Y. pestis dissemination.

So it looks like the traders using routes along the Silk Road, the main conduit for commerce between Europe and East Asia, may have brought along more than expensive goods for their unwitting customers.

Scary stuff.  I hasten to add that although Yersinia pestis is still endemic in wild animal populations, not only in remote places like Tian Shan but in Africa (there have been recent outbreaks in Madagascar and the Democratic Republic of Congo) and the southwestern United States/northern Mexico, it is now treatable with antibiotics if caught early enough.  So unlike the viral disease epidemics we're currently fighting, at least we have a weapon against this one once you've contracted it, and it's unlikely to wreak the havoc now that it did in the past.

At least we are no longer in the situation of horrified bewilderment that people like Nick Calladine were, as they watched their world shattering right before their eyes.  "My father was one of the first to take ill, in July, when the plague came, and he was dead the same day," Nick says.  "My sister sickened and died two days later, her throat swollen with the black marks that some have said are the devil’s handprints.  They were two of the first, but it didn’t end there.  In three weeks nearly the whole village of Ashbourne was dead, and I left alive to wonder at how quickly things change, and to think about the message in Father Jerome’s last sermon, that the plague was the hand of God striking down the wicked.  I wonder if he thought about his words as he lay dying himself at sundown of the following day."

Although we still don't have the entire causal sequence figured out, we've come a long way from attributing disease to God's wrath.  With Spyrou et al.'s new research, we've added another link to the chain -- identifying the origins of a disease that within ten years, had exploded out of its home in Central Asia to kill millions, and change the course of history forever.

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Downplaying a pandemic

Let me be up front that I'm fully in favor of freedom of speech and freedom of the press.

That said, I have to ask: what the fuck are the people who run Fox News thinking?

They've been irresponsible before.  Hell, they've lied outright before.  (Yes, yes, I know other media are guilty of the same thing.  If your only defense of your behavior is "He does it, too!", you might want to consider whether you have a defensible point in the first place.)  But yesterday morning, I saw a clip from Fox Business that aired Monday night and takes irresponsibility and dishonesty to new and unscaled heights.

Those of you keep your eyes on the news no doubt already know that I'm talking about Trish Regan's rant about how the COVID-19 pandemic is being deliberately used by Democrats to take down Donald Trump.  (If you doubt that's the message, consider that the banner next to her during the entire segment said, "Coronavirus Impeachment Scam.")  Here's the bit that stood out:

The chorus of hate being leveled at the President is nearing a crescendo as Democrats blame him -- and only him -- for a virus that originated halfway around the world.  This is yet another attempt to impeach the President.  And sadly it seems they care very little for any of the destruction they are leaving in their wakes.  Losses in the stock market, all this unfortunately just part of the political casualties for them...  The hate is boiling over.  Many in the liberal media are using -- and mean using -- coronavirus in an attempt to demonize and destroy the President.

First, to correct a few of the most egregious lies.

No one blames Trump for the virus.  The virus is a naturally-occurring pathogen that does what it does irrespective of your nationality or political leanings.  What a lot of people are blaming him for is his bungled handling of the pandemic response, starting with the fact of his calling it a "hoax" at one of his rallies.  Yeah, okay, he amended it later, saying he only meant that the Democrats' response to it had been a hoax, but look, I watched the video clip.  The exact quote was, "Now the Democrats are politicizing the coronavirus.  They have no clue, they can't even count their votes in Iowa.  This is their new hoax."

If you don't come away from listening to that with the message, "The coronavirus pandemic is a hoax," you're much better at reading between the lines than I am.

All along, Trump's reaction has been to downplay the seriousness of the situation.  After a visit to the CDC, he did a press conference in which he said -- again, this is verbatim: "As of the time I left the plane with you, we had 240 cases.  That's at least what was on a very fine network known as Fox News.  And you love it.  But that's what I happened to be watching.  And how was the show last night?  Did it get good ratings, by the way?  I heard it broke all ratings records, but maybe that's wrong.  That's what they told me."

Meh, 240 cases.  No biggie.  But look at my ratings, amirite?

He also said that the number of cases in Italy was decreasing (it wasn't), that anyone in the United States who wanted a COVID-19 test could have one (they can't), and that the pandemic was going to be good for the economy because people wouldn't go overseas to spend their money.

[Image is in the Public Domain, courtesy of the Center for Disease Control]

So sorry, Trish, no one, liberal or conservative, is saying Trump is to blame for the virus.  No one, liberal or conservative, wants to see the stock market crash.  (That's a personal one for me; I retired last June, and have been in a state of panic watching my investments sliding into the abyss.)

But this goes beyond an ill-informed, ignorant talking head spewing nonsense.  Because this nonsense is gonna kill people.

Don't believe me?  Already this morning on social media, I've seen the following:

• The media need to simmer down.  They're making people panic for no reason.
• I can't believe they hate the president so much they would make up a plague to destroy the economy just to take him down.
• I heard it's not very contagious.  I'm not worried.  I'm more worried about what the liberals are trying to do to our country.
• We'll have a vaccine in a couple of weeks, and then this will be over and forgotten just like all the other leftist attempts to destroy the United States.
• Only old people who are already sick are in danger.

Now let's look at what actual epidemiologists are saying.

The World Health Organization and the CDC are in agreement that realistically, by the time the dust settles between 40% and 70% of the world's population will have been infected.  If the 2% mortality rate figure holds (and taking the mean value of 55% infected), that means 77 million people dead.

Which is twice the total killed by the Spanish flu -- the deadliest pandemic on record.

What Trish Regan did on Fox Business two nights ago puts people's lives in danger by convincing them the risk is minimal.  China got ahead of the epidemic by enacting the largest quarantine in the history of the world.  At the moment, Italy is following suit, and has the entire damn country on lockdown -- no unnecessary travel, stay home except for emergencies.  They're taking this seriously, as well they should.

But with idiots like Trish Regan trying to convince everyone that the whole thing is a plot by the evil Democrats to ruin Donald Trump, how much likelihood is there of that working here -- and even if it were mandated, for people to go along with it?

Look, I'm a biologist.  I know enough about viruses and disease pathology that I don't panic every time the flu goes around in winter.  But this thing is qualitatively different.  This has the potential to kill a huge number of people, especially older people and those with compromised immune systems.

Like I said, I support free speech and freedom of the press.  But this is shouting "fire!" in a crowded theater.  And I hope like hell I'm wrong, but my gut tells me that Trish Regan and Fox News are going to be responsible for a lot of people dying before this is over.

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This week's Skeptophilia book-of-the-week is brand new: Brian Greene's wonderful Until the End of Time.

Greene is that wonderful combination, a brilliant scientist and a lucid, gifted writer for the scientifically-inclined layperson.  He'd already knocked my socks off with his awesome The Elegant Universe and The Fabric of the Cosmos (the latter was made into an equally good four-part miniseries).

Greene doesn't shy away from difficult topics, tackling such subjects as relativity, quantum mechanics, and the nature of time.  Here, Greene takes on the biggest questions of all -- where the universe came from, how it has evolved and is evolving, and how it's going to end.

He begins with an observation that as a species, we're obsessed with the ideas of mortality and eternity, and -- likely unique amongst known animals -- spend a good part of our mental energy outside of "the now," pondering the arrow of time and what its implications are.  Greene takes a lens to this obsession from the standpoint of physics, looking at what we know and what we've inferred about the universe from its beginnings in the Big Bang to its ultimate silent demise in the "Heat Death" some billions or trillions of years in the future.

It's definitely a book that takes a wide focus, very likely the widest focus an author could take.  And in Greene's deft hands, it's a voyage through time you don't want to miss.

[Note: if you purchase this book using the image/link below, part of the proceeds goes to support Skeptophilia!]

A pandemic of conspiracies

I have to admit that COVID-19 has me a little skittish.

I know all the reassuring bits -- that most people who contract it have few or no symptoms, that the mortality rate is only 2% (contrast that with 70% mortality rate for a monster like Ebola-Zaire), that the flu is worse and we don't panic about that every year.

But.  I've read The Stand and watched Outbreak, and the similarities are alarming, not in the symptoms or severity, but in how the government is handling it.  Outright incompetence, coupled with attempts to muzzle the news media, along with reassurances that are almost certainly false ("a vaccine will be widely available soon").  There was a cluster of cases in Kirkland, Washington -- where I lived for ten years -- and just this morning there was the confirmation of a case...

... in Manhattan.

So at the moment I'm oscillating between "guarded" and "freaking right the fuck out."

At least I keep telling myself to go back to the facts -- what the CDC has discovered about the virus, recommendations for avoiding getting sick, maps of actual cases.  Which is more than I can say for a few other people.

Situations like this always seem to be prime breeding ground for conspiracy theories.  My explanation for this is that people are happier believing that there's a cause for Bad Stuff Happening even if the cause itself is kind of horrifying than they are believing that bad things just happen because they happen.  Global evil is, for some reason, more comforting than simple chaos.

But still.  There are some people who should, in Will Rogers's words, never miss a good opportunity to shut up.

Top of that list is New Zealand-based evangelical Christian preacher Brian Tamaki, of the Destiny Church of Auckland, who said this weekend that COVID-19 wasn't actually a virus, it was an airborne demon, and that therefore True Believers were immune.

"Satan has control of atmospheres unless you're a born-again, Jesus-loving, Bible-believing, Holy Ghost-filled, tithe-paying believer," Tamaki said, with special emphasis on the "tithe-paying" part.

"You're the only one that can walk through atmospheres and have literally a protection, the PS-91 protection policy."  PS-91, by the way, isn't a medication.  It's code for Psalm 91, wherein we read, "Surely he will save you from the fowler's snare or the deadly pestilence."

Because that worked out so well for people during the Black Death.

Tamaki, though, was hardly the only one who's been saying that coronavirus wasn't an ordinary epidemic.  The announcement by the World Health Organization that COVID-19 is now officially a pandemic was followed nearly immediately by Donald Trump announcing at a rally that the outbreak is a "hoax" by the Democrats to discredit him.  How the Democrats created a virus in China and then spread it all over the world is a matter of conjecture, but the MAGA-crowd isn't exactly known for their critical thinking skills, so there was an immediate outcry against those evil Democrats trying to damage Dear Leader.  Then when someone pointed out that it was odd, if the epidemic was caused by the Democrats trying to gain political advantage, the first states to have confirmed cases were strongly liberal-leaning -- California, Oregon, Washington, and New York.

"No," the MAGAs responded.  "The Democrats did that on purpose!  They're making themselves sick so they can blame it on Donald Trump!"

Because that's how evil we liberals are.  Mwa ha ha ha *cough, hack, sneeze* ha ha ha ha ha.

But no one has a better conspiracy theory (and by "better" I mean "completely batshit insane") than the one my wife found a couple of days ago.  Because a summary wouldn't nearly do it justice, here it is in all its glory:

"Digitized RNA activated by 5G waves."  "Remote assassination."  "Smart dust from chemtrails."  "ID2020."  "Weaponized technology from the Space Force."

And, of course, rejecting vaccines.

Look, I know it's scary.  I know it's natural to try to find reasons for things, because once you see the reasons, you can control the fear.

But that is no excuse for making shit up.

Let's all just calm down, take as many precautions as we can (including, most importantly, wash your damn hands).  Panicking and inventing crazy fairy tales and conspiracy theories doesn't solve anything or help anyone.  There's no reason to overreact.

Now, y'all'll have to excuse me, because I'm off to put on my hazmat suit and enter my underground bunker for the next three months.

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This week's Skeptophilia book-of-the-week is brand new -- science journalist Lydia Denworth's brilliant and insightful book Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond.

Denworth looks at the evolutionary basis of our ability to form bonds of friendship -- comparing our capacity to that of other social primates, such as a group of monkeys in a sanctuary in Puerto Rico and a tribe of baboons in Kenya.  Our need for social bonds other than those of mating and pair-bonding is deep in our brains and in our genes, and the evidence is compelling that the strongest correlate to depression is social isolation.

Friendship examines social bonding not only from the standpoint of observational psychology, but from the perspective of neuroscience.  We have neurochemical systems in place -- mediated predominantly by oxytocin, dopamine, and endorphin -- that are specifically devoted to strengthening those bonds.

Denworth's book is both scientifically fascinating and also reassuringly optimistic -- stressing to the reader that we're built to be cooperative.  Something that we could all do with a reminder of during these fractious times.

[Note: if you purchase this book using the image/link below, part of the proceeds goes to support Skeptophilia!]

An epidemic of lunacy

Humans are odd creatures sometimes.

We have a regrettable tendency to abandon reason entirely when we're confronted with scary circumstances.  I suppose it's understandable enough; we're emotional as well as logical, and when we're frightened the emotional parts of our brain tend to swamp the more rational bits.

Still, it'd be nice if we could control that tendency, because it would help to reduce our likelihood of falling for weird counterfactual explanations at the times that it's the most critical for us to keep our  heads screwed on straight.

Take, for example, the most recent Scary Circumstance, namely, the outbreak of Wuhan coronavirus that so far has killed just over a hundred people, sickened thousands, and (by some estimates) left over a hundred thousand people at risk of exposure.

Coronaviruses [Image is in the Public Domain, courtesy of the CDC]

Worrisome stuff, isn't it?  The potential for a pandemic is there, and the unknowns about the virus still outnumber the knows -- the rate at which it's passed on (what the epidemiologists refer to as "R0"), whether it's mutating as it spreads, what the mortality rate is, whether it's contagious while an individual is still asymptomatic.  But as I alluded to earlier, "frightening unknown virus" does not equate to "I think I'll make bizarre shit up."

Let's start with something I've now seen four times on social media, although I couldn't find a good link to the origin of the claim.  This particular flavor of nonsense is that the coronavirus outbreak is particularly dangerous to a specific subset of humanity...

... people who have been vaccinated for other diseases.

It will come as no surprise that the people who are spreading this foolishness are the anti-vaxxers.  How exactly a vaccine for (say) mumps would make you more likely to contract coronavirus they never explain.  The reason for that, of course, is that there is no explanation, because the claim itself is idiotic.  The anti-vaxxers are simply looking for another horrible thing to blame on vaccines, and the Big Bad Guys pushing vaccination -- doctors and "Big Pharma."  And since there is no actual evidence vaccines are dangerous, and ample evidence they reduce your risk of a number of deadly diseases to near zero, if you're going to claim otherwise you pretty much have to spin your argument from whole cloth.

That feeling when you're so ignorant about vaccines you end up reinventing them by mistake.  [Screencap from Twitter]

Then, there's the even more insidious approach of the insane conspiracy theory group QAnon, who have a two-part claim: (1) that Bill Gates patented the Wuhan coronavirus in 2015 and is using it to kill off the weak in some sort of bizarre eugenics experiment; and (2) that all you have to do to cure a coronavirus infection is to drink bleach.

As far as the first part, I don't know what to say except "are you fucking kidding me right now?"  The second part, though, has been around for a while -- the bleach solution ("Miracle Mineral Solution," which contains chlorine dioxide, a highly toxic compound) has been touted as a cure-all for all sorts of viral and bacterial infections.  And the claim is correct in a sense; if you have a coronavirus infection and you drink Miracle Mineral Solution, you won't be sick any more.

You'll be dead.

Lastly, from the "How Do People This Stupid Exist?" department, we have the folks who apparently think that coronavirus has something to do with Corona beer, other than the fact that "corona" appears in both names.

Corona, I hasten to point out (probably unnecessarily), is the Latin word for "crown."  The virus got that name because it's covered with spiky projections that look a little bit crown-like; the beer was given that name because its manufacturers wanted people to think it was the King of Beers (another incorrect claim, as the King of Beers is clearly Guinness).  But the similarity between the names has evidently led some people to think that there is more to it than that, and Google searches for "beer virus" have gone through the roof.

What exactly people think the connection is, I have no idea.  My hopeful side tells me that maybe people are just wanting to find out if anyone really is silly enough to think that the beer contains the virus.  But my gut tells me that it's more likely there really are people who believe the beer is transmitting the virus, or the beer cures the virus, or possibly both at the same time.

Who the hell knows?

Anyhow -- until such time as a coronavirus vaccine is developed, the best way to avoid catching or passing on infection is to do what you (hopefully) are doing already during flu season -- wash your hands frequently, cover your mouth when you cough or sneeze, and if you're sick yourself, stay home.  Other than that, try to resist the temptation to let your emotions carry you away.  Epidemics are bad enough without loopy speculation getting in the way.

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The brilliant, iconoclastic physicist Richard Feynman was a larger-than-life character -- an intuitive and deep-thinking scientist, a prankster with an adolescent sense of humor, a world traveler, a wild-child with a reputation for womanizing.  His contributions to physics are too many to list, and he also made a name for himself as a suspect in the 1950s "Red Scare" despite his work the previous decade on the Manhattan Project.  In 1986 -- two years before his death at the age of 69 -- he was still shaking the world, demonstrating to the inquiry into the Challenger disaster that the whole thing could have happened because of an o-ring that shattered from cold winter temperatures.

James Gleick's Genius: The Life and Science of Richard Feynman gives a deep look at the man and the scientist, neither glossing over his faults nor denying his brilliance.  It's an excellent companion to Feynman's own autobiographical books Surely You're Joking, Mr. Feynman! and What Do You Care What Other People Think?  It's a wonderful retrospective of a fascinating person -- someone who truly lived his own words, "Nobody ever figures out what life is all about, and it doesn't matter.  Explore the world.  Nearly everything is really interesting if you go into it deeply enough."

[Note: if you purchase this book using the image/link below, part of the proceeds goes to support Skeptophilia!]

Trapped in the ice

Today in the "I've Seen This Movie, And It Didn't End Well" department, we have: scientists digging into glacial ice and finding heretofore-undiscovered species of viruses and bacteria.

Just this week, a paper called "Glacier Ice Archives Fifteen-Thousand-Year-Old Viruses" was released as a preprint on bioRxiv, detailing work by a team led by Zhi-Ping Zhong of Ohio State University.  Here's what the scientists themselves write about the research:

While glacier ice cores provide climate information over tens to hundreds of thousands of years, study of microbes is challenged by ultra-low-biomass conditions, and virtually nothing is known about co-occurring viruses.  Here we establish ultra-clean microbial and viral sampling procedures and apply them to two ice cores from the Guliya ice cap (northwestern Tibetan Plateau, China) to study these archived communities...  The microbes differed significantly across the two ice cores, presumably representing the very different climate conditions at the time of deposition that is similar to findings in other cores.  Separately, viral particle enrichment and ultra-low-input quantitative viral metagenomic sequencing from ∼520 and ∼15,000 years old ice revealed 33 viral populations (i.e., species-level designations) that represented four known genera and likely 28 novel viral genera (assessed by gene-sharing networks).  In silico host predictions linked 18 of the 33 viral populations to co-occurring abundant bacteria, including Methylobacterium, Sphingomonas, and Janthinobacterium, indicating that viruses infected several abundant microbial groups.  Depth-specific viral communities were observed, presumably reflecting differences in the environmental conditions among the ice samples at the time of deposition. 

On the face of it, it's unsurprising they're finding new viruses, because we find new viruses wherever we look in modern ecosystems.  Viruses are so small that unless you're specifically looking for them, you don't see them.

But four new genera of viruses is a little eyebrow-raising, because that means we're talking about viruses that aren't closely related to anything we've ever seen before.

This, of course, brings up the inevitable question, which was the first thing I thought of; what if one of these new viruses turns out to be pathogenic to humans?  The majority of viruses don't cause disease in humans, but it only takes one.  Science fiction is rife with people messing around with melting ice and releasing horrors -- this was the basic idea of The Thing, not to mention The X Files episode "Ice" and best of all (in my opinion) the horrifying, thrilling, and heartbreaking Doctor Who episode "The Waters of Mars," which is in my top five favorites in the entire history of the series.

So I'm hoping like hell the research team is being cautious.  Not that it ever made any difference in science fiction.  Somebody always fucks up, and large amounts of people end up getting sick, eaten, or converted to some horrifying new form that goes around killing everyone.

Lest you think I'm just being an alarmist because I've watched too many horror movies, allow me to point out that this sort of thing has already happened.  In 2016, permafrost melt in Siberia released frozen anthrax spores that sickened almost a hundred people, one fatally, and killed over two thousand reindeer -- after that region not seeing a single case of anthrax for at least seventy years.

On the other hand, it's understandable that the scientists are acting quickly, because the way things are going in the climate, glaciers will be a thing of the past in fairly short order.  Glaciers and polar ice sheets are time capsules, layer by layer preserving information about the climatic conditions when the ice was deposited, even trapping air bubbles that act as proxy records giving us information about the atmospheric composition at the time.  (This is one of the ways we've obtained carbon dioxide concentrations going back tens of thousands of years.)

However, it also preserves living things, including some that seem to retain their ability to be resuscitated nearly indefinitely.  I try not to panic over every little risk, but I have to admit this one has me spooked.  We don't have a stellar track record for caution, but our track record for saying, "Oh, yeah, this'll work!" and then unleashing a catastrophe is a good bit more consistent.

So let's be careful, okay, scientists?  I'm all for learning whatever we can learn, but I'd rather not be turned into a creepy evil being with a scaly face dripping toxic contagious water all over the place.  Call me picky, but there it is.

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This week's Skeptophilia book of the week is scarily appropriate reading material in today's political climate: Robert Bartholomew and Peter Hassall's wonderful A Colorful History of Popular Delusions.  In this brilliant and engaging book, the authors take a look at the phenomenon of crowd behavior, and how it has led to some of the most irrational behaviors humans are prone to -- fads, mobs, cults, crazes, manias, urban legends, and riots.

Sometimes amusing, sometimes shocking, this book looks at how our evolutionary background as a tribal animal has made us prone all too often to getting caught up in groupthink, where we leave behind logic and reason for the scary territory of making decisions based purely on emotion.  It's unsettling reading, but if you want to understand why humans all too often behave in ways that make the rational ones amongst us want to do repeated headdesks, this book should be on your list.

[Note: if you purchase this book using the image/link below, part of the proceeds goes to support Skeptophilia!] 

Preventing the unknown

Some days it's no great mystery why the general public is dubious about scientists.

I mean, a lot of it is the media, as I've discussed here at Skeptophilia ad nauseam.  But there are times that the scientists themselves put their best foot backward.  As an example, consider the announcement from the World Health Organization this week that their Research & Development Blueprint for priority diseases includes "Disease X."

A disease that is as-yet unidentified.

The blueprint itself says this:

Disease X represents the knowledge that a serious international epidemic could be caused by a pathogen currently unknown to cause human disease, and so the R&D Blueprint explicitly seeks to enable cross-cutting R&D preparedness that is also relevant for an unknown “Disease X” as far as possible.

On the one hand, there's a grain of sense there.  Recognizing the fact that there are "emerging diseases" that are apparently new to humanity, and that could cause epidemics is the first step toward readying ourselves for when that happens.  (Recent examples are Ebola and Lassa fever, Marburg virus, Severe Acute Respiratory Syndrome (SARS), and chikungunya.)

The Ebola virus [image courtesy of the World Health Organization]

But still.  What the WHO is telling the public is that they're putting time and effort into preventing an epidemic from a disease that:

• may not exist
• if it does exist, has unknown symptoms, origins, and mode of transmission
• may or may not be preventable
• may or may not be treatable
• may or may not be highly communicable
• may or may not be carried by other animals
• is of unknown duration and severity

Is it just me, or does this seem like an exercise in futility?

Like I said, an awareness of the unpredictability of disease outbreaks is a start, but this seems like trying to nail jello to the wall.  Each time humanity has been faced with a potential pandemic, we've had to study the disease and how it moves from one host to another, scramble to find treatments for the symptoms while we're searching for an actual cure (or better yet, a vaccine to prevent it), and do damage control in stricken areas.  So I can't see where the "Disease X" approach gets us, except to put everyone on red alert for an epidemic that may never happen.

I think my eyerolling when I read about this comes from two sources.  First, I'm all too aware that life is risky, and although it's certainly laudable to try to reduce the risk as much as you can, the bare fact is that you can't remove it entirely.  After all, none of us here are getting out of this place alive.  And second, there is an unavoidable chaotic element to what happens -- we get blindsided again and again by bizarre occurrences, and the professional prognosticators (not to mention professional psychics) get it wrong at least as often as they get it right.

So there probably will eventually be a new emerging epidemic.  On a long enough time scale, there's probably going to be a true pandemic as well.  I hope that with our advances in medical research, we'll be able to respond in time to prevent what happened during the Black Death, or worse, the Spanish flu epidemic of 1918 to 1919, that killed an estimated 40 million people (over twice the number of deaths as the battlefield casualties of World War I, which was happening at the same time).

In one sense, I take back what I said about not being able to do anything about it ahead of time.  We can give ourselves the best shot at mitigating the effects of an outbreak -- by funding medical research, and encouraging our best and brightest to go into science (i.e., education, a topic I've also rung the changes on more than once).  Other than that, I'm just going to eat right, exercise, and hope for the best.

Historical hype, government coverups, and the "Spanish flu"

At the heart of skepticism is a philosophy that says, basically, "question everything."  I would add a few "especiallies:"

• especially if the claim appeals to your personal biases and fears;
• especially if it seems sensationalized;
• especially if there is no hard data to support it;
• and especially if it's claiming that the reason there's no data is because of a government coverup.

 I ran into an excellent example of this just yesterday, with an article on The Liberty Digest titled, "U.S. Government Kills 100 Million People -- Deflects All Blame," by Truman Jackson.  My first thought was to wonder how 100 million people could have died without my noticing, but upon opening the link I found that he wasn't talking about something recent.

He was talking about the "Spanish flu."

An influenza hospital at Camp Funston, Kansas, winter 1918 (photograph courtesy of the Wikimedia Commons)

What followed was such a mixture of truth, half truth, and complete bullshit that the author should win some kind of award for Best Example of Journalistic Hash, 2013.  Here's his claim, to which I've added a few annotations of my own:

Consider this a history lesson. At the time, it was an experiment in attrition and public gullibility, and both experiments proved favorable to ‘the powers that be’ as far as the outcome obtained.

It’s referred to as the Great Spanish Flu Pandemic of 1918 in the history books, but there was nothing Spanish about this plague that killed between 20 million and 100 million people world-wide. [True.  It was the worst pandemic in modern history, rivaling or perhaps exceeding the 14th century Black Death.]  It was 100% U.S. Government controlled and engineered.  [Bullshit.]

In a nutshell, while mass troop movements were heading to Europe during WWI, the U.S. Government, through the Department of the Army, was experimenting with this really neat, and new for the time, technology, called vaccines.  [True.]  They were injecting flu vaccine, among others, into soldiers who were on their way to fight in the “war to end all wars.”  [False, and not only false, but impossible.  The first flu vaccines weren't developed until 1931, twelve years after the epidemic, and World War I, both ended.]

As everyone knows, most vaccines have a strain of that of which they are supposed to be preventing, and in this case, a common strain of flu common for the U.S. at least.  [True in essence.]

However, the strain was not common in Europe and the rest of the world and the other people who inhabited those countries had not had a chance for their immune systems to develop any defense against the U.S. flu strain.  [True, but misleading, because this more or less happens every year -- that's why there are epidemics.  If people had a "defense" against a strain, they wouldn't get sick.  It doesn't require some sort of deliberate attempt by the U.S. to spread the disease, the virus is perfectly capable of doing that on its own.]

The result was catastrophic, and some would say diabolical. Nearly 5% of the earth’s surface population at the time was killed by the outbreak of the flu.  ["Diabolical" implies intent, so while the percent mortality is accurate, the implication is not.]

How did Spain get the blame?

Simple.

The ‘powers that be’ who were involved with the war made sure to keep a tight lid on the story of the flu. They feared world-wide riots should the populace learn the facts behind how far and wide the outbreak had spread. However, Spain was “neutral” during the war, and they openly reported on the havoc the virus was causing in their country. As a result they ended up getting the blame for the outbreak, and nothing could have pleased the ‘powers that be’ more. Remember, no good dead [sic] goes unpunished.  [Bullshit.  Although the author is correct that the identification of Spain as the origin of the epidemic was probably false, no one was trying to "blame Spain" for some sort of geopolitical reason, any more than calling the 1968 "Hong Kong flu" was an attempt to blame China.]

Many experts who have written on the “Spanish” influenza which killed upwards of 100 million people, believe the virus actually originated at an Army base in Kansas.  [Half-truth.  The origins of the virus are still uncertain.  Epidemiologists have proposed France, Austria, and China as alternate explanations, but the fact is, we don't know where it came from.]

So what we have here is the usual conspiracy nonsense, bolstered by people's fears of the side effects of vaccination due to the insidious work of such discredited nutjobs as Andrew Wakefield and Jenny McCarthy.

Of course, the timing of this article is no coincidence; the 2013-2014 flu season is just ramping up, and people are considering whether to get vaccinated.  Anti-vaxx hype is big this year, although studies debunking the supposed horrible side effects of vaccines clearly demonstrate that the risks of vaccination are vastly outweighed by the risks of contracting preventable diseases.  Flu kills thousands of people yearly, and most years the vaccine does a pretty good job of preventing the disease.  (I have to use the qualifiers "most" and "pretty good" because the flu virus is notorious for mutating, and the vaccine is based upon a best-guess of what the strains that year will be.  Every so often, the researchers don't get it right, and there's a strain prevalent that the vaccine doesn't immunize you against.  Even so, they get it right far more often than they get it wrong, and the benefit still far outweighs the risk.)

But no wonder that this article is making the rounds of social media, anti-vaxx websites, anti-government websites, and conspiracy theory websites.  It hits all of my "especiallies;" it caters to preconceived biases and fears, it's sensationalized, it has nothing in the way of data proving its points, and it claims that the reason for the lack of evidence is a conspiracy.

The nice thing about the Internet Age is that we have virtually instantaneous access to information, and with a little bit of training, anyone can learn to sift the truth from the bullshit.  Start, for example, by looking only at sources that are peer-reviewed -- it's not a guarantee of accuracy, but at least you've raised the bar from the kind of tripe published in places like The Liberty Digest.  Ask questions, especially "how does the author know this claim is true?"  Question your own biases and assumptions.

And never, ever accept what someone says without evidence.